CAS 124932-61-2|Big Endothelin-1 (22-38), human
Introduction：Basic information about CAS 124932-61-2|Big Endothelin-1 (22-38), human, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Big Endothelin-1 (22-38), human | ||
|---|---|---|---|
| CAS Number | 124932-61-2 | Molecular Weight | 1808.99000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C80H125N23O25 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Big Endothelin-1: 22-38, human |
|---|
Big Endothelin-1 (22-38), human BiologicalActivity
| Description | Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| In Vitro | Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs[2]. |
| In Vivo | Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly[3]. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3]. |
| References | [1]. Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97. [2]. D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5. [3]. Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5. |
Chemical & Physical Properties
| Molecular Formula | C80H125N23O25 |
|---|---|
| Molecular Weight | 1808.99000 |
| Exact Mass | 1807.92000 |
| PSA | 754.44000 |
