CAS 87468-58-4|Biotin-Substance P

Introduction：Basic information about CAS 87468-58-4|Biotin-Substance P, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameBiotin-Substance P
CAS Number87468-58-4Molecular Weight1573.93000
Density/Boiling Point/
Molecular FormulaC73H112N20O15S2Melting Point/
MSDS/Flash Point/

Names

NameBiotin-Substance P,Biotin-RPKPQQFFGLM-NH2
SynonymMore Synonyms

Biotin-Substance P BiologicalActivity

DescriptionBiotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].
Related CatalogSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
In VitroThe neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
References

[1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

Chemical & Physical Properties

Molecular FormulaC73H112N20O15S2
Molecular Weight1573.93000
Exact Mass1572.81000
PSA611.44000
LogP5.42560
InChIKeyVTEGKDUGRAEBSX-UDPLRNBMSA-N
SMILESCSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)CCCCC1SCC2NC(=O)NC21)C(N)=O
Storage condition-20°C

Synonyms

Substance p,N2-(5-(hexahydro-2-oxo-1H-thieno(3,4-D)imidazol-4-yl)-1-oxopentyl)-,(3as-(3aalpha,4beta,6aalpha))
BIOTINYL-SUBSTANCE P
BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
Abasp
BIOTIN-SUBSTANCE P
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
BIOTIN-RPKPQQFFGLM-NH2
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