CAS 520-85-4|medroxyprogesterone
Introduction：Basic information about CAS 520-85-4|medroxyprogesterone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | medroxyprogesterone | ||
|---|---|---|---|
| CAS Number | 520-85-4 | Molecular Weight | 344.488 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 488.0±45.0 °C at 760 mmHg |
| Molecular Formula | C22H32O3 | Melting Point | 220-223.5ºC |
| MSDS | ChineseUSA | Flash Point | 263.0±25.2 °C |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | medroxyprogesterone |
|---|---|
| Synonym | More Synonyms |
medroxyprogesterone BiologicalActivity
| Description | Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.Target: Progesterone ReceptorMedroxyprogesterone (MP), is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is an metabolite of MPA [1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>Endocrinology |
| References | [1]. http://en.wikipedia.org/wiki/Medroxyprogesterone |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 488.0±45.0 °C at 760 mmHg |
| Melting Point | 220-223.5ºC |
| Molecular Formula | C22H32O3 |
| Molecular Weight | 344.488 |
| Flash Point | 263.0±25.2 °C |
| Exact Mass | 344.235138 |
| PSA | 54.37000 |
| LogP | 3.38 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.554 |
| InChIKey | FRQMUZJSZHZSGN-HBNHAYAOSA-N |
| SMILES | CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 6 mg/kg/13W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 163,51,1995 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 17-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 625 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,445,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1120 mg/kg
- SEX/DURATION :
- male 16 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 187,431,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7306 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Phrases | 48-63-68 |
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU5300000 |
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Synonyms
| Medroxyprogesteron |
| Medroxyprogesteronum |
| Hydroxymethylprogesterone |
| MFCD00069474 |
| 17α-Hydroxy-6α-methylprogesterone |
| Medroxy Progesterone |
| 17-Hydroxy-6α-methylprogesterone |
| Medrossiprogesterone |
| 17alpha-Hydroxy-6alpha-methylprogesterone |
| (6a)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione |
| 17-Hydroxy-6a-methylprogesterone |
| Medroxiprogesterone |
| 17a-Hydroxy-6a-methylprogesterone |
| 17-Hydroxy-6alpha-methylprogesterone |
| 6a-Methyl-17a-hydroxyprogesterone |
| 6α-Methyl-17α-hydroxyprogesterone |
| Farlutal |
| 17α-Hydroxy-6α-methylpregn-4-ene-3,20-dione |
| EINECS 208-298-6 |
| (6α)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione |
| Pregn-4-ene-3,20-dione, 17-hydroxy-6α-methyl- |
| medroxyprogesterone |
| (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6α)- |
| Medroxiprogesteronum |
| Pregn-4-ene-3,20-dione, 17α-hydroxy-6α-methyl- |
| Medroxyprogesterone Base |
