Introduction：Basic information about CAS 2445-83-2|7-Methylcoumarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect[1].
Related Catalog
Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References
[1]. Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
313.1±0.0 °C at 760 mmHg
Melting Point
128-130 °C(lit.)
Molecular Formula
C10H8O2
Molecular Weight
160.17
Flash Point
125.9±19.5 °C
Exact Mass
160.052429
PSA
30.21000
LogP
1.85
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.583
InChIKey
DLHXRDUXNVEIEY-UHFFFAOYSA-N
SMILES
Cc1ccc2ccc(=O)oc2c1
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GN7792100
CHEMICAL NAME :
Coumarin, 7-methyl-
CAS REGISTRY NUMBER :
2445-83-2
BEILSTEIN REFERENCE NO. :
0122625
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H8-O2
MOLECULAR WEIGHT :
160.18
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
258 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7980 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)
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