CAS 28094-15-7|Oxidopamine hydrochloride
Introduction：Basic information about CAS 28094-15-7|Oxidopamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxidopamine hydrochloride | ||
|---|---|---|---|
| CAS Number | 28094-15-7 | Molecular Weight | 205.63900 |
| Density | / | Boiling Point | 406ºC at 760 mmHg |
| Molecular Formula | C8H12ClNO3 | Melting Point | 232-233ºC (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 199.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 6-Hydroxy Dopamine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Oxidopamine hydrochloride BiologicalActivity
| Description | Oxidopamine hydrochloride is a neurotoxic synthetic organic compound, selectively destroys dopaminergic and noradrenergic neurons in the brain. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
Chemical & Physical Properties
| Boiling Point | 406ºC at 760 mmHg |
|---|---|
| Melting Point | 232-233ºC (dec.)(lit.) |
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.63900 |
| Flash Point | 199.3ºC |
| Exact Mass | 205.05100 |
| PSA | 86.71000 |
| LogP | 1.80690 |
| Vapour Pressure | 3.58E-07mmHg at 25°C |
| InChIKey | QLMRJHFAGVFUAC-UHFFFAOYSA-N |
| SMILES | Cl.NCCc1cc(O)c(O)cc1O |
| Storage condition | 2-8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,411,1977
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| RIDADR | NONH for all modes of transport |
| RTECS | DC4650000 |
Articles175
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| LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson's disease. Neurol. Sci. 36 , 2027-33, (2015) Lysophosphatidic acid (LPA) is a bioactive phospholipid that activates at least five known G-protein-coupled receptors (GPCRs): LPA1-LPA5. The nervous system is a major locus for LPA1 expression. LPA ... |
Synonyms
| 6-Hydroxydopamine hydrochloride |
| 6-HYDROXYDOPAMINE HYDROCHLORIDE |
| 5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride |
| Oxidopamine (hydrochloride) |
