Introduction：Basic information about CAS 102115-79-7|Pseudoprotodioscin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pseudoprotodioscin |
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| CAS Number | 102115-79-7 | Molecular Weight | 1031.184 |
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| Density | 1.45 g/cm3 | Boiling Point | / |
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| Molecular Formula | C51H82O21 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | protogracellin |
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| Synonym | More Synonyms |
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Pseudoprotodioscin BiologicalActivity
| Description | Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>MicroRNASignaling Pathways >>Metabolic Enzyme/Protease >>Fatty Acid Synthase (FAS)Research Areas >>Metabolic Disease |
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| In Vitro | In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1]. |
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| References | [1]. Gai Y, et al. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393. [2]. Liang ZZ, et al. Oligofurostanosides from Asparagus cochinchinensis. Planta Med. 1988 Aug;54(4):344-6. |
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Chemical & Physical Properties
| Density | 1.45 g/cm3 |
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| Molecular Formula | C51H82O21 |
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| Molecular Weight | 1031.184 |
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| Exact Mass | 1030.534912 |
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| PSA | 325.83000 |
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| LogP | 5.31 |
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| Index of Refraction | 1.631 |
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| InChIKey | MDCUMTGKKLOMCW-VZFURQGKSA-N |
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| SMILES | CC1=C(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C12 |
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Safety Information
| Safety Phrases | S24/25 |
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| HS Code | 29389090 |
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Synonyms
| PSEUDOPROTOTRIBESTIN |
| β-D-Glucopyranoside, (25R)-3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy]furosta-5,20(22)-dien-27-yl |
| (3β,25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->;2)-[6-deoxy-α-L-mannopyranosyl-(1->;4)]-β-D-glucopyranoside |
| pseudo-Protodioscin |
| PROTODIOSCIN,PSEUDO |
| β-D-Glucopyranoside, (25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]- |
| (25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside |
| Pseduoprotodioscin |
| (25R)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy}furosta-5,20(22)-dien-27-yl β-D-glucopyranoside |
| β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]- |
| Pseudoprotodioscin |
