Introduction：Basic information about CAS 23811-08-7|Agarospirol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Agarospirol |
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| CAS Number | 23811-08-7 | Molecular Weight | 222.366 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 312.2±11.0 °C at 760 mmHg |
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| Molecular Formula | C15H26O | Melting Point | 59-60°C (lit.) |
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| MSDS | / | Flash Point | 114.6±15.6 °C |
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Names
| Name | hinesol |
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| Synonym | More Synonyms |
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Agarospirol BiologicalActivity
| Description | (-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | (-)-Hinesol (0-25 µg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change for the total protein levels of IκBα and p65 in A549 cells[1]. Cell Proliferation Assay[1] Cell Line: A549, NCI-H1299 cells Concentration: 0-25 µg/ml Incubation Time: 24, 48 h Result: Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Induced apoptosis with the apoptotic cells was increased to 21.2 ± 0.96% and 36 ± 1.04% after treatment with hinesol at 2 and 8 μg/mL, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Increased the protein expression of Bax and decreased the expression of Bcl-2. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase. |
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| References | [1]. Guo W, et al. The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299. J Cell Biochem. 2019 Nov;120(11):18600-18607. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 312.2±11.0 °C at 760 mmHg |
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| Melting Point | 59-60°C (lit.) |
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| Molecular Formula | C15H26O |
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| Molecular Weight | 222.366 |
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| Flash Point | 114.6±15.6 °C |
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| Exact Mass | 222.198364 |
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| PSA | 20.23000 |
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| LogP | 4.67 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.505 |
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| InChIKey | ICWHTQRTTHCUHW-OWYJLGKBSA-N |
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| SMILES | CC1=CCCC(C)C12CCC(C(C)(C)O)C2 |
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Safety Information
Customs
| HS Code | 2906199090 |
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| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| 2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]propan-2-ol |
| Agarospirol |
| Spiro[4.5]dec-6-ene-2-methanol, α,α,6,10-tetramethyl-, (2S,5R,10R)- |
| 2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]-2-propanol |
