Introduction：Basic information about CAS 59870-65-4|Glabrol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Glabrol |
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| CAS Number | 59870-65-4 | Molecular Weight | 392.48700 |
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| Density | 1.166g/cm3 | Boiling Point | 600ºC at 760 mmHg |
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| Molecular Formula | C25H28O4 | Melting Point | 121-123 C |
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| MSDS | / | Flash Point | 204.3ºC |
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Names
| Name | 7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one |
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Glabrol BiologicalActivity
| Description | Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1]. |
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| Target | ratACAT:24.6 μM (IC50) |
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| In Vitro | Glabrol (Compound 1) decreases cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells[1]. |
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| References | [1]. Choi JH, et al. Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. J Ethnopharmacol. 2007 Apr 4;110(3):563-6. |
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Chemical & Physical Properties
| Density | 1.166g/cm3 |
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| Boiling Point | 600ºC at 760 mmHg |
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| Melting Point | 121-123 C |
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| Molecular Formula | C25H28O4 |
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| Molecular Weight | 392.48700 |
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| Flash Point | 204.3ºC |
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| Exact Mass | 392.19900 |
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| PSA | 66.76000 |
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| LogP | 5.82170 |
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| Index of Refraction | 1.599 |
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| InChIKey | CUFAXDWQDQQKFF-DEOSSOPVSA-N |
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| SMILES | CC(C)=CCc1cc(C2CC(=O)c3ccc(O)c(CC=C(C)C)c3O2)ccc1O |
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