CAS 288-32-4|Imidazole
Introduction：Basic information about CAS 288-32-4|Imidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Imidazole | ||
|---|---|---|---|
| CAS Number | 288-32-4 | Molecular Weight | 68.077 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 257.0±9.0 °C at 760 mmHg |
| Molecular Formula | C3H4N2 | Melting Point | 88-91 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 145.0±0.0 °C |
| Symbol | GHS05, GHS07, GHS08 | Signal Word | Danger |
Names
| Name | 1H-imidazole |
|---|---|
| Synonym | More Synonyms |
Imidazole BiologicalActivity
| Description | Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor.Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins. Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersBiochemical Assay ReagentsResearch Areas >>Others |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 257.0±9.0 °C at 760 mmHg |
| Melting Point | 88-91 °C(lit.) |
| Molecular Formula | C3H4N2 |
| Molecular Weight | 68.077 |
| Flash Point | 145.0±0.0 °C |
| Exact Mass | 68.037445 |
| PSA | 28.68000 |
| LogP | -0.16 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.528 |
| InChIKey | RAXXELZNTBOGNW-UHFFFAOYSA-N |
| SMILES | c1c[nH]cn1 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture. |
| Water Solubility | 633 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 626 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 880 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 817 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 475 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - rigidity (including catalepsy) Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 760 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - impotence
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1601 No. of Facilities: 158 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1401 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1601 No. of Facilities: 313 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3009 (estimated) No. of Female Employees: 2411 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1601 No. of Facilities: 158 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1401 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1601 No. of Facilities: 313 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3009 (estimated) No. of Female Employees: 2411 (estimated)
Safety Information
| Symbol | GHS05, GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314-H360D |
| Precautionary Statements | P201-P260-P280-P303 + P361 + P353-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C:Corrosive |
| Risk Phrases | R22;R34;R63 |
| Safety Phrases | S26-S36/37/39-S45-S22-S36 |
| RIDADR | UN 2923 8/PG 3 |
| WGK Germany | 1 |
| RTECS | NI3325000 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| IMD |
| 1,3-Diaza-2,4-cyclopentadiene,Glyoxaline |
| GLYOXALIN |
| LMIDAZOLE |
| glioksal |
| 1,3-diaza-2,4-cyclopentadiene |
| Imidazol |
| Miazole |
| 1,3-imidazole |
| Imidazoie |
| Imidazole |
| MFCD00005183 |
| 1-imidazole |
| EINECS 206-019-2 |
| Imidazole buffer |
| IMINAZOLE |
| 1,3-diazole |
| Imutex |
| Clotrimazole Impurity 4 |
