Introduction：Basic information about CAS 604769-01-9|R306465, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | R306465 |
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| CAS Number | 604769-01-9 | Molecular Weight | 413.45 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C19H19N5O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-hydroxy-2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)pyrimidine-5-carboxamide |
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| Synonym | More Synonyms |
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R306465 BiologicalActivity
| Description | JNJ-16241199 is an orally active, selective hydroxamate-based histone deacetylase (HDAC) inhibitor, with the IC50 of 3.3 nM and 23 nM for HDAC1 and HDAC8, respectively. JNJ-16241199 induces histone 3 acetylation and strongly increases the expression of p21waf1, cip1 in A2780 ovarian carcinoma cells. JNJ-16241199 induces cell apoptosis and shows anticancer activity in a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>HDACSignaling Pathways >>Epigenetics >>HDAC |
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| Target | HDAC1:3.3 nM (IC50) HDAC8:23 nM (IC50) |
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| References | [1]. Arts J, et al. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. Br J Cancer. 2007;97(10):1344-1353. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C19H19N5O4S |
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| Molecular Weight | 413.45 |
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| Exact Mass | 413.115784 |
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| PSA | 124.11000 |
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| LogP | 2.06 |
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| Index of Refraction | 1.689 |
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| InChIKey | MUTBJZVSRNUIHA-UHFFFAOYSA-N |
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| SMILES | O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| N-Hydroxy-2-[4-(2-naphthylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamide |
| 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- |
| unii-5wd7kk1iiq |
| R306465 |
| JNJ-16241199 |
