CAS 2189-80-2|Taraxeryl acetate

Introduction：Basic information about CAS 2189-80-2|Taraxeryl acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Taraxeryl acetate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Taraxeryl acetate
CAS Number	2189-80-2	Molecular Weight	468.754
Density	1.0±0.1 g/cm3	Boiling Point	505.1±49.0 °C at 760 mmHg
Molecular Formula	C₃₂H₅₂O₂	Melting Point	303-305ºC
MSDS	/	Flash Point	256.2±17.4 °C

Names

Name	taraxerol acetate
Synonym	More Synonyms

Taraxeryl acetate BiologicalActivity

Description	Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis[1].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>COX
Target	COX-1:116.3 μM (IC50) COX-2:94.7 μM (IC50)
In Vitro	Taraxerol acetate(10-150 µM; 24 or 48 hours) induces a dose- and time-dependent cytotoxic effects in the U87 cells, exhibits IC50 values of 34.2 and 28.4 µM, at 24 and 48 h, respectively[2]. Taraxerol acetate(10, 50 and 150 µM; 24 hours) induces cell apoptosis, the percentage of apoptotic cells increased from 7.3% in the control cells, to 16.1, 44.1 and in the 10, 50 and 150 µM taraxerol acetate-treated cells, respectively. Furthermore, taraxerol acetate treatment led to sub-G1 cell cycle arrest with a corresponding decrease in the number of S-phase cells[2].
References	[1]. Ubaid Ur Rehman1 A, et al. Molecular docking of taraxerol acetate as a new COX inhibitor. Journal of the Bangladesh Pharmacological Society [2]. Hong JF, et al. Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration.Mol Med Rep. 2016 Jun;13(6):4541-8.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	505.1±49.0 °C at 760 mmHg
Melting Point	303-305ºC
Molecular Formula	C₃₂H₅₂O₂
Molecular Weight	468.754
Flash Point	256.2±17.4 °C
Exact Mass	468.396729
PSA	26.30000
LogP	11.95
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.529
InChIKey	YWJGYBXHXATAQY-MZVVBVDXSA-N
SMILES	CC(=O)OC1CCC2(C)C3CCC4(C)C(=CCC5(C)CCC(C)(C)CC54)C3(C)CCC2C1(C)C

Safety Information

Hazard Codes	Xi

Synonyms

Taraxerol monoacetate

3-Picenol, 1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-eicosahydro-4,4,6a,8a,11,11,12b,14b-octamethyl-, acetate, (3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-

Friedoolean-14-en-3-yl acetate

D-Friedoolean-14-en-3beta-yl acetate

Acetyl taraxerol

Taraxerol Acetate

Taraxenol acetate

(3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydro-3-picenyl acetate

(3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydropicen-3-yl acetate

taraxeryl acetate

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