Introduction：Basic information about CAS 2673-40-7|Perivine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Perivine |
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| CAS Number | 2673-40-7 | Molecular Weight | 338.400 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 541.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H22N2O3 | Melting Point | 180-181ºC |
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| MSDS | / | Flash Point | 281.0±30.1 °C |
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Names
| Name | Perivine |
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| Synonym | More Synonyms |
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Perivine BiologicalActivity
| Description | Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | IC50: Retinoblastoma-associated proteins (RbAp48)[1] |
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| In Vitro | Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy[1]. |
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| References | [1]. Hung-Jin Huang, et al. Lead Discovery for Alzheimer's Disease Related Target Protein RbAp48 From Traditional Chinese Medicine. Biomed Res Int |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 541.1±50.0 °C at 760 mmHg |
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| Melting Point | 180-181ºC |
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| Molecular Formula | C20H22N2O3 |
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| Molecular Weight | 338.400 |
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| Flash Point | 281.0±30.1 °C |
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| Exact Mass | 338.163055 |
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| PSA | 71.19000 |
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| LogP | 3.53 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.652 |
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| InChIKey | NKTORRNHKYVXSU-XXMLWKDOSA-N |
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| SMILES | CC=C1CNC2Cc3c([nH]c4ccccc34)C(=O)CC1C2C(=O)OC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- ZB1740000
- CHEMICAL NAME :
- Vobasan-17-oic acid, 4-demethyl-3-oxo-, methyl ester
- CAS REGISTRY NUMBER :
- 2673-40-7
- BEILSTEIN REFERENCE NO. :
- 0046952
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H22-N2-O3
- MOLECULAR WEIGHT :
- 338.44
- WISWESSER LINE NOTATION :
- T E6 D586 A KM NV PY RM&&TTJ AVO1 PU2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- 33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975 Volume(issue)/page/year: -,73,1975
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Safety Information
Synonyms
| 2,6-Methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R,14S)- |
| 2,6-methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R)- |
| 3-oxo-22-nor-vobasan-17-oic acid methyl ester |
| X1201 |
| Methyl (1S,14R,15E,18S)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate |
| Methyl (1S,14R,15E)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate |
| Vobasan-17-oic acid,4-demethyl-3-oxo-,methyl ester |
| Perivin |
| 3-Oxo-22-nor-vobasan-17-saeure-methylester |
