Introduction：Basic information about CAS 178603-78-6|Caspase-1 Inhibitor II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Caspase-1 Inhibitor II |
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| CAS Number | 178603-78-6 | Molecular Weight | 540.994 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 969.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C24H33ClN4O8 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 539.9±34.3 °C |
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Names
| Name | ac-yvad-cmk |
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| Synonym | More Synonyms |
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Caspase-1 Inhibitor II BiologicalActivity
| Description | Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
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| Target | Caspase-1 |
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| In Vitro | Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2]. |
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| In Vivo | Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2]. Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3]. |
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| References | [1]. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. [2]. Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. [3]. Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 969.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C24H33ClN4O8 |
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| Molecular Weight | 540.994 |
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| Flash Point | 539.9±34.3 °C |
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| Exact Mass | 540.198669 |
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| PSA | 191.00000 |
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| LogP | 1.93 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.554 |
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| InChIKey | UOUBHJRCKHLGFB-DGJUNBOTSA-N |
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| SMILES | CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CCl)C(C)C |
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| Storage condition | -20°C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | AY3079566 |
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Synonyms
| Ac-YVAD-cmk |
| N-Ac-Tyr-Val-Ala-Asp-CMK |
| AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE |
| AC-YVAD-CHLOROMETHYLKETONE |
| AC-TYR-VAL-ALA-ASP-CH2CL |
| AC-TYR-VAL-ALA-ASP-CMK |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]-L-alaninamide |
| PASE-1 INHIBITOR II |
| ICE INHIBITOR II |
| IL-1BETA CONVERTING ENZYME INHIBITOR II |
| L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]- |
| AC-TYR-ALA-ASP-CHLOROMETHYLKETONE |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-alaninamide |
