CAS 107761-24-0|ST638

Introduction：Basic information about CAS 107761-24-0|ST638, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ST638 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles25
8. Synonyms

Common Name	ST638
CAS Number	107761-24-0	Molecular Weight	354.423
Density	1.3±0.1 g/cm3	Boiling Point	611.2±55.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₈N₂O₃S	Melting Point	134-135.5ºC
MSDS	ChineseUSA	Flash Point	323.5±31.5 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide
Synonym	More Synonyms

ST638 BiologicalActivity

Description	ST638 is a potent tyrosine kinase inhibitor with an IC50 of 370 nM[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Fuortes M, et al. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol. 1993 Feb;120(3):777-84.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	611.2±55.0 °C at 760 mmHg
Melting Point	134-135.5ºC
Molecular Formula	C₁₉H₁₈N₂O₃S
Molecular Weight	354.423
Flash Point	323.5±31.5 °C
Exact Mass	354.103821
PSA	121.64000
LogP	2.34
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.656
InChIKey	YKLMGKWXBLSKPK-RIYZIHGNSA-N
SMILES	CCOc1cc(C=C(C#N)C(N)=O)cc(CSc2ccccc2)c1O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC6316200

CHEMICAL NAME :: 2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)p henyl)-

CAS REGISTRY NUMBER :: 107761-24-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H18-N2-O3-S

MOLECULAR WEIGHT :: 354.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UC6316200
HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles25

The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells.

Int. J. Immunopharmacol. 17(5) , 433-41, (1995)

It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. ...

Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors.

Pflugers Arch. 446(4) , 485-91, (2003)

The present study investigated the effects of protein tyrosine kinase inhibitors on the fast sodium current ( I(Na)) in rabbit ventricular myocytes. Single rabbit ventricular myocytes were isolated en...

Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.

Cell Physiol. Biochem. 13(3) , 165-72, (2003)

Polymorphonuclear leukocytes (neutrophils) release a variety of toxic agents--proteins and reactive oxygen species (ROS)--that are used to inactivate foreign microorganisms in the non-specific immune ...

Synonyms

2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-, (2E)-

MFCD00236446

(2E)-2-Cyano-3-{3-ethoxy-4-hydroxy-5-[(phenylsulfanyl)methyl]phenyl}acrylamide

ST638 (pharmaceutical)

2-Propenamide,2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]

ST 638

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