Introduction：Basic information about CAS 113378-31-7|Semduramicin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Semduramicin |
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| CAS Number | 113378-31-7 | Molecular Weight | 873.07500 |
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| Density | 1.27g/cm3 | Boiling Point | 921.3ºC at 760mmHg |
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| Molecular Formula | C45H76O16 | Melting Point | / |
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| MSDS | / | Flash Point | 262.8ºC |
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Names
| Name | Semduramicin |
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| Synonym | More Synonyms |
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Semduramicin BiologicalActivity
| Description | Semduramicin (UK-61689) is an orally active anticoccidial agent with an IC50 value of 30.0 ng/mL for E. tenella. Semduramicin reduces the lesions of E. aceroulina, E. brunetti and E. maxima. Semduramicin (20-30 mg/kg) is well tolerates in broilers and possesses broad spectrum anticoccidial activity. Semduramicin can be used in beef and poultry industry as coccidian inhibitor and growth promoter[1][2][3]. |
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| Related Catalog | Research Areas >>Infection |
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| In Vitro | Semduramicin (25 mg/L；48 h) 显著减少了堆型艾美耳球虫、布氏艾美耳球虫和巨型艾美耳球虫的病变[1]。 Semduramicin 显示出主要的革兰氏阳性抗菌谱[3]。 Semduramicin 的抗菌谱[3] Strain Lactobacillus acidophilus Lactobacillus spp. Streptococcus zooepidemicus Clostridium perfringens Bacteroides fragilis B.vulgatus MIC (µg/mL) 1.56 6.25 4.68 6.25-12.5 50 100 |
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| In Vivo | Semduramicin (25 mg/kg；口服，6-8 天) 显著改善了被球虫感染的十日龄肉鸡公鸡的体重增加、病变以及死亡率[1]。 Semduramicin (7.5-120 mg/kg；口服，6 天) 对十天大的白来亨鸡中的柔嫩艾美耳球虫有抑制作用[3]。 Animal Model: Ten-day-old broiler cockerels[1]. Dosage: 25 mg/kg. Administration: Oral gavage; 6-8 days. Result: Effectively controlled mortality, lesions, and weight gain depression that occurred. Animal Model: Ten-day-old White Leghorn chicks[3]. Dosage: 7.5, 15, 20, 30, 40, 60 and 120 mg/kg. Administration: Oral gavage; 6 days. Result: Significantly inhibited weight gain over 60 mg/kg and increased lesions below 20 mg/kg. |
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| References | [1]. Logan NB, at al. Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests. Poult Sci. 1993 Nov;72(11):2058-63. [2]. Cao V, et al. Treatment of Lasalocid A, Salinomycin and Semduramicin as ionophore antibiotics in pharmaceutical wastewater by PAMAM-coated membranes[J]. Environmental Technology & Innovation, 2020, 20: 101103. [3]. Ricketts A P, et al. Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia[J]. Poultry science, 1992, 71(1): 98-103. |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Boiling Point | 921.3ºC at 760mmHg |
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| Molecular Formula | C45H76O16 |
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| Molecular Weight | 873.07500 |
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| Flash Point | 262.8ºC |
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| Exact Mass | 872.51300 |
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| PSA | 210.52000 |
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| LogP | 4.03790 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.56 |
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| InChIKey | WINSLRIENGBHSH-ASZYJFLUSA-N |
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| SMILES | COC1CCC(OC2CC(C3OC(C)(O)C(C)CC3C)OC2C2(C)CCC(C3(C)CCC4(CC(O)C(C)C(C(C)C5OC(O)(CC(=O)O)C(C)C(O)C5OC)O4)O3)O2)OC1C |
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Synonyms
| 2H-Pyran-2-acetic acid,tetrahydro-2,4-dihydroxy-6-(1R)-1-(2S,5R,7S,8R,9S)-9-hydroxy-2,8-dimethyl-2-(2S,2R,3S,5R,5R)-octahydro-2-methyl-5-(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl-3-(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran |
| Semduramycin |
