Introduction：Basic information about CAS 96829-59-3|(-)-Lipstatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (-)-Lipstatin |
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| CAS Number | 96829-59-3 | Molecular Weight | 491.70 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 627.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C29H49NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 333.2±31.5 °C |
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Names
| Name | [(2S,4E,7E)-1-(3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl] (2S)-2-formamido-3-methylpentanoate |
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| Synonym | More Synonyms |
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(-)-Lipstatin BiologicalActivity
| Description | Lipstatin is a very potent pancreatic lipase inhibitor can be isolated from Streptomyces toxytricini. Lipstatin inhibits the hydrolysis of trioleate by porcine pancreatic lipase with an IC50 of 0.14 μM[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | Lipstatin（20、60 mg/kg；口服；单剂量；3 天）剂量依赖性地抑制三油酸甘油酯的吸收，而油酸在小鼠体内吸收正常[1]。 |
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| References | [1]. Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40(8): 1081-1085. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 627.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C29H49NO5 |
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| Molecular Weight | 491.70 |
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| Flash Point | 333.2±31.5 °C |
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| Exact Mass | 491.361084 |
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| PSA | 81.70000 |
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| LogP | 8.05 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.485 |
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| InChIKey | OQMAKWGYQLJJIA-FOVDAUFBSA-N |
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| SMILES | CCCCCC=CCC=CCC(CC1OC(=O)C1CCCCCC)OC(=O)C(CC(C)C)NC=O |
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Synonyms
| L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester |
| (2S-(2alpha(1R*,3Z,6Z),3beta))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester |
| (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic acid lactone |
| L-Leucine,N-formyl-,1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester,(2S-(2alpha(1R*,3Z,6Z),3beta)) |
| (2S,3S,5S,7Z,1OZ)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic 1,3 acid lactone |
| (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl N-formyl-L-leucinate |
| (2S-(2α(1R*,3Z,6Z),3β))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester |
| lipstatin |
| (-)-lipstatin |
| (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-4,7-tridecadien-2-yl N-formyl-L-leucinate |
| (2S-(2a(1R*,3Z,6Z),3b))-N-Formyl-L-leucine 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl Ester |
