Introduction：Basic information about CAS 76956-02-0|Lavoltidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lavoltidine |
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| CAS Number | 76956-02-0 | Molecular Weight | 359.46600 |
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| Density | 1.23g/cm3 | Boiling Point | 566.9ºC at 760 mmHg |
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| Molecular Formula | C19H29N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | 296.6ºC |
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Names
| Name | loxtidine |
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| Synonym | More Synonyms |
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Lavoltidine BiologicalActivity
| Description | Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H2 Receptor |
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| In Vivo | Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis-infected INS-GAS mice[1]. Lavoltidine treatment for 6 months inhibits gastric tumors in H felis-infected INS-GAS mice[1]. Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis[1] Dosage: 0.5 g/L Administration: Orally (drinking water); changed weekly; for 3 months Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia. |
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| References | [1]. Takaishi S, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. |
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Chemical & Physical Properties
| Density | 1.23g/cm3 |
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| Boiling Point | 566.9ºC at 760 mmHg |
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| Molecular Formula | C19H29N5O2 |
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| Molecular Weight | 359.46600 |
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| Flash Point | 296.6ºC |
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| Exact Mass | 359.23200 |
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| PSA | 75.44000 |
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| LogP | 2.18520 |
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| Index of Refraction | 1.614 |
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| InChIKey | VTLNPNNUIJHJQB-UHFFFAOYSA-N |
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| SMILES | Cn1nc(CO)nc1NCCCOc1cccc(CN2CCCCC2)c1 |
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Synonyms
| LAVOLTIDINE |
| Lavoltidina |
| Lavoltidinum |
| [1-methyl-5-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]-1,2,4-triazol-3-yl]methanol |
| Loxtidinum |
| Loxtidina |
| Loxtidine |
| Lavoltidinum [INN-Latin] |
| Loxtidinum [Latin] |
| Lavoltidine [INN:BAN] |
| Loxtidina [Spanish] |
