Introduction：Basic information about CAS 89391-50-4|IMIRESTAT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IMIRESTAT |
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| CAS Number | 89391-50-4 | Molecular Weight | 286.23300 |
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| Density | 1.58g/cm3 | Boiling Point | / |
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| Molecular Formula | C15H8F2N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione |
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| Synonym | More Synonyms |
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IMIRESTAT BiologicalActivity
| Description | Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Aldose ReductaseResearch Areas >>Metabolic Disease |
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| In Vivo | Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity[1]. |
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| References | [1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401. |
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Chemical & Physical Properties
| Density | 1.58g/cm3 |
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| Molecular Formula | C15H8F2N2O2 |
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| Molecular Weight | 286.23300 |
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| Exact Mass | 286.05500 |
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| PSA | 58.20000 |
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| LogP | 2.68580 |
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| Index of Refraction | 1.692 |
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| InChIKey | QCCHBHSAIQIQGO-UHFFFAOYSA-N |
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| SMILES | O=C1NC(=O)C2(N1)c1cc(F)ccc1-c1ccc(F)cc12 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WH1307300
- CHEMICAL NAME :
- Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-
- CAS REGISTRY NUMBER :
- 89391-50-4
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C15-H8-F2-N2-O2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 mg/kg/14D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 700 mg/kg/14D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997
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Synonyms
| Imirestatum [INN-Latin] |
| Alcon 1576 |
| 2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione |
| 2,7-di-fluoro-spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione |
| Imirestat |
| spiro-[2,7-difluorofluoren-9,4'-imidazolidine]-2',5'-dione |
| Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,2,7-difluoro |
| [14C]-Imirestat |
| Spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione |
| HOE 843 |
