Introduction：Basic information about CAS 113170-55-1|L-Ascorbic acid 2-phosphate magnesium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Ascorbic acid 2-phosphate magnesium |
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| CAS Number | 113170-55-1 | Molecular Weight | 278.393 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C6H9O9P.3/2Mg | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate |
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| Synonym | More Synonyms |
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L-Ascorbic acid 2-phosphate magnesium BiologicalActivity
| Description | L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| Target | IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3] |
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| In Vitro | L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1]. L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3]. Cell Viability Assay[1] Cell Line: Human corneal endothelial cells (HCECs) Concentration: 0.1 mM; 0.3 mM; 1.5 mM Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days Result: Stimulated HCEC cells growth. |
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| References | [1]. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. [2]. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. [3]. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17. |
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Chemical & Physical Properties
| Molecular Formula | C6H9O9P.3/2Mg |
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| Molecular Weight | 278.393 |
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| Exact Mass | 277.967804 |
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| PSA | 169.22000 |
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| InChIKey | XYWDYAVMJYSSSG-LEJBHHMKSA-N |
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| SMILES | O=C1OC(C(O)CO)C(O)=C1OP(=O)(O)O.[Mg] |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36/37/39 |
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| HS Code | 2835100000 |
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Customs
Synonyms
| trimagnesium,[(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl] phosphate |
| L-Ascorbic Acid 2-Phosphate Sesquimagnesium Salt Hydrate |
| Magnesium (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydro-3-furanyl phosphate |
| MFCD08063372 |
