Introduction：Basic information about CAS 17908-57-5|β-MSH (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | β-MSH (human) trifluoroacetate salt |
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| CAS Number | 17908-57-5 | Molecular Weight | 2660.92000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C118H174N34O35S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | β-Melanocyte Stimulating Hormone human |
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| Synonym | More Synonyms |
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β-MSH (human) trifluoroacetate salt BiologicalActivity
| Description | β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Melanocortin ReceptorResearch Areas >>Neurological DiseasePeptidesResearch Areas >>Metabolic Disease |
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| Target | Melanocortin[1] |
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| In Vitro | β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2]. |
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| In Vivo | β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2]. |
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| Animal Admin | Mice[1] Male ICR mice weighing 23-25 g are housed under standard conditions (21-23°C, 12 h light-dark cycle) with unlimited access to food and water. The NO contents in the mouse forebrains are measured 6 h after drug administration using an electron paramagnetic resonance (EPR) method. β-Melanocyte Stimulating Hormone is administered intracisternaly (i.c.) with or without LPS, in a total injection volume of 10 μL (i.e., saline or 10 μL LPS with β-Melanocyte Stimulating Hormone ranging from 1 to 3 nM per animal). Control animals receive i.c. injection of 10 μL saline. The mice then receive intraperitoneal injections of spin trap reagents, i.e., 400 mg/kg DETC followed by subcutaneous injections of ferrous citrate (40 mg/kg ferrous sulphate+200 mg/kg sodium citrate, prepared directly in the syringe just before use), 0.5 h before decapitation. Thus, the spin trap reagents are administered 5.5 h after the LPS and peptide administration, when decapitation is performed 6 h after the start of the experiment. After that the forebrains are dissected and immediately frozen in liquid nitrogen. |
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| References | [1]. Muceniece R, et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol. 2005 Dec;169(1-2):13-9. [2]. Harrold JA, et al. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24(3):397-405. |
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Chemical & Physical Properties
| Molecular Formula | C118H174N34O35S |
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| Molecular Weight | 2660.92000 |
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| Exact Mass | 2659.26000 |
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| PSA | 1146.64000 |
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| LogP | 2.49690 |
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| InChIKey | XLLJFSCSXTYVTN-UHFFFAOYSA-N |
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| SMILES | CSCCC(NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(C)N)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CO)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)O |
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| Storage condition | −20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| MFCD00167548 |
| β-Melanocyte stimulating hormone human |
| |A-MSH human |
| β-Melanocyte Stimulating Hormone (MSH), human |
