CAS 22374-89-6|4-phenylbutan-2-amine

Introduction：Basic information about CAS 22374-89-6|4-phenylbutan-2-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Preparation
6. Customs
7. Articles6
8. Synonyms

Common Name	4-phenylbutan-2-amine
CAS Number	22374-89-6	Molecular Weight	149.233
Density	0.9±0.1 g/cm3	Boiling Point	221.5±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₅N	Melting Point	-50ºC
MSDS	ChineseUSA	Flash Point	97.8±0.0 °C
Symbol	GHS05	Signal Word	Danger

Names

Name	4-phenylbutan-2-amine
Synonym	More Synonyms

Chemical & Physical Properties

Density	0.9±0.1 g/cm3
Boiling Point	221.5±0.0 °C at 760 mmHg
Melting Point	-50ºC
Molecular Formula	C₁₀H₁₅N
Molecular Weight	149.233
Flash Point	97.8±0.0 °C
Exact Mass	149.120453
PSA	26.02000
LogP	2.18
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.522
InChIKey	WECUIGDEWBNQJJ-UHFFFAOYSA-N
SMILES	CC(N)CCc1ccccc1
Storage condition	−20°C
Water Solubility	8.5 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UI3920000

CHEMICAL NAME :: Propylamine, alpha-methyl-gamma-phenyl-

CAS REGISTRY NUMBER :: 22374-89-6

BEILSTEIN REFERENCE NO. :: 2413110

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H15-N

MOLECULAR WEIGHT :: 149.26

WISWESSER LINE NOTATION :: ZY1&2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

Safety Information

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C: Corrosive;Xi: Irritant;T: Toxic;F: Flammable;
Risk Phrases	R22;R34
Safety Phrases	26-36/37/39-45-28A-36/37
RIDADR	UN 2735 8/PG 3
WGK Germany	2
RTECS	UI3920000
Packaging Group	III
HS Code	29214980

Preparation

Customs

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles6

Quantification of Methylphenidate, Dexamphetamine, and Atomoxetine in Human Serum and Oral Fluid by HPLC With Fluorescence Detection.

Ther. Drug Monit. 38 , 98-107, (2016)

For psychostimulants, a marked individual variability in the dose-response relationship and large differences in plasma concentrations after similar doses are known. Therefore, optimizing the efficacy...

Identification and quantitation of an oxidative metabolite of labetalol in sheep: pharmacokinetic and metabolic implications.

Biol. Mass Spectrom. 21(11) , 534-40, (1992)

A sensitive and selective assay has been developed for the identification and quantitation of 3-amino-1-phenyl butane (3-APB), a metabolite of labetalol, in biological fluids using electron impact gas...

Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep.

Drug Metab. Dispos. 21(2) , 284-92, (1993)

Labetalol causes significant maternal and fetal metabolic effects in pregnant sheep (Yeleswaram et al., J. Pharmacol. Exp. Ther. 262, 683-691 (1992)). This study was undertaken to investigate the cont...

Synonyms

DL-1-methyl-3-phenyl-n-propylamine

α-Methyl phenethylamine

1-Methyl-3-phenylpropylamine

Benzenepropanamine, α-methyl-

1-phenyl-3-aminobutane

4-phenylbutan-2-amine

3-Amino-1-phenylbutane

EINECS 244-942-2

(RS)-1-methyl-3-phenylpropylamine

(+/-)-1-methyl-3-phenylpropylamine

4-Phenyl-2-aminobutane

4-Phenyl-2-butanamine

UNII:326655W66Z

α-Methylbenzenepropanamine

MFCD00056185

4-Phenyl-2-butylamine

2-Amino-4-phenylbutane

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