CAS 2410-93-7|2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentane

Introduction：Basic information about CAS 2410-93-7|2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles10
7. Synonyms

Common Name	2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
CAS Number	2410-93-7	Molecular Weight	455.42400
Density	1.61g/cm3	Boiling Point	/
Molecular Formula	C₂₀H₂₁N₇O₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
Synonym	More Synonyms

BiologicalActivity

Description	Methopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Li P, et al. [Effects of methopterin on osteoclasts and study of its mechanism of action]. Yao Xue Xue Bao. 2008 Oct;43(10):1025-31.

Chemical & Physical Properties

Density	1.61g/cm3
Molecular Formula	C₂₀H₂₁N₇O₆
Molecular Weight	455.42400
Exact Mass	455.15500
PSA	204.75000
LogP	1.36390
Index of Refraction	1.732
InChIKey	HLIXOCXUWGDBNP-ZDUSSCGKSA-N
SMILES	CN(Cc1cnc2nc(N)[nH]c(=O)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0700000

CHEMICAL NAME :: Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylami no)benzoyl)-

CAS REGISTRY NUMBER :: 2410-93-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N7-O6

MOLECULAR WEIGHT :: 455.48

WISWESSER LINE NOTATION :: T66 BN DN GN JNJ CZ EQ H1NVR D1Z&YVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,688,1955

Safety Information

RIDADR	NONH for all modes of transport

Articles10

The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.

Lancet 2(8242) , 337-40, (1981)

It is suggested that in man the methyl folate trap is a normal physiological response to impending methyl group deficiency resulting from a very low supply of methionine. This decreases cellular S-ade...

Enhancement of recovery from psychiatric illness by methylfolate.

Lancet 336(8712) , 392-5, (1990)

41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l)...

Differential effects of stimulus termination on excitation and desensitization of folic acid receptors and guanylate cyclase in Dictyostelium discoideum.

Biochim. Biophys. Acta 930(1) , 1-9, (1987)

The response of guanylate cyclase to addition of extracellular stimuli is well documented. Here we report for the first time the response of guanylate cyclase to removal of stimuli. Three methods were...

Synonyms

N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]benzoyl]glutaMic Acid

N(10)-methylfolate

N-(10-methyl-pteroyl)-L-glutamic acid

N-[4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid

Methotrexate impurity C

10-Methylpteroylglutamic acid

N10-methylfolic acid

N10-MethylpteroylglutaMic Acid

N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid

N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

1-methylfolic acid

N-(10-Methyl-pteroyl)-L-glutaminsaeure

10-methylpteroylglutamlic acid

N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid

2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

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