Introduction：Basic information about CAS 23052-80-4|L-AP3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-AP3 |
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| CAS Number | 23052-80-4 | Molecular Weight | 169.07 |
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| Density | 1.763 g/cm3 | Boiling Point | 481.6ºC at 760 mmHg |
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| Molecular Formula | C3H8NO5P | Melting Point | 227-229ºC |
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| MSDS | ChineseUSA | Flash Point | 245.1ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | (2R)-2-amino-3-phosphonopropanoic acid |
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| Synonym | More Synonyms |
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L-AP3 BiologicalActivity
| Description | L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| In Vitro | L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively[1]. L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM)[1]. L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1]. |
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| In Vivo | L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1]. |
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| References | [1]. J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. |
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Chemical & Physical Properties
| Density | 1.763 g/cm3 |
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| Boiling Point | 481.6ºC at 760 mmHg |
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| Melting Point | 227-229ºC |
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| Molecular Formula | C3H8NO5P |
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| Molecular Weight | 169.07 |
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| Flash Point | 245.1ºC |
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| Exact Mass | 169.01400 |
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| PSA | 130.66000 |
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| Vapour Pressure | 1.34E-10mmHg at 25°C |
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| InChIKey | LBTABPSJONFLPO-REOHCLBHSA-N |
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| SMILES | NC(CP(=O)(O)O)C(=O)O |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2931900090 |
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Preparation
Customs
| HS Code | 2931900090 |
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| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (2S)-2-amino-3-phosphonopropionic acid |
| L(+)-2-Amino-3-phosphonopropionic acid |
| L(+)-2-Amino-3-phosphonopropionic acidL-AP3 |
| (R)-2-Amino-3-phosphonopropanoic acid |
| (R)-(+)-2-AMINO-3-PHOSPHONOPROPIONIC ACID |
| L-AP3 |
| (S)-(+)-2-amino-3-phosphonopropanoic acid |
| 3-PHOSPHONO-L-ALANINE |
| MFCD00083169 |
| Phosphonoalanine |
| (2R)-2-Amino-3-phosphonopropionic acid |
| L(+)-2-AMINO-3-PHOSPHONOPROPANOIC ACID |
| phosphoserine |
