CAS 89-00-9|Quinolinic acid
| Common Name | Quinolinic acid | ||
|---|---|---|---|
| CAS Number | 89-00-9 | Molecular Weight | 167.119 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 425.0±30.0 °C at 760 mmHg |
| Molecular Formula | C7H5NO4 | Melting Point | 188-190ºC |
| MSDS | ChineseUSA | Flash Point | 210.9±24.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | quinolinic acid |
|---|---|
| Synonym | More Synonyms |
Quinolinic acid BiologicalActivity
| Description | Quinolinic acid is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 425.0±30.0 °C at 760 mmHg |
| Melting Point | 188-190ºC |
| Molecular Formula | C7H5NO4 |
| Molecular Weight | 167.119 |
| Flash Point | 210.9±24.6 °C |
| Exact Mass | 167.021851 |
| PSA | 87.49000 |
| LogP | -1.44 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.628 |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cccnc1C(=O)O |
| Storage condition | Store at RT |
| Water Solubility | 0.55 g/100 mL |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1050 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 46,323,1994
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | US7967250 |
| HS Code | 29333999 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans. J. Neuroinflammation 12 , 110, (2015) During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydrox... | |
| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days... |
Synonyms
| 2,3-Pyridinedicarboxylic acid |
| MFCD00006295 |
| EINECS 201-874-8 |
| Quinolinic acid |
| UNII-F6F0HK1URN |
| T6NJ BVQ CVQ |
| Pyridine-2,3-dicarboxylic acid |
