Introduction：Basic information about CAS 328-90-5|4-Trifluoromethylsalicylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Trifluoromethylsalicylic acid (Desacetyl triflusal) is a platelet aggregation inhibitor[1].
Related Catalog
Research Areas >>OthersSignaling Pathways >>Others >>Others
References
[1]. Rodríguez G, et al. Hydrophilic polymer drug from a derivative of salicylic acid: synthesis, controlled release studies and biological behavior. Macromol Biosci. 2004;4(6):579-586.
Chemical & Physical Properties
Density
1.5±0.1 g/cm3
Boiling Point
286.4±40.0 °C at 760 mmHg
Melting Point
178ºC
Molecular Formula
C8H5F3O3
Molecular Weight
206.119
Flash Point
127.0±27.3 °C
Exact Mass
206.019073
PSA
57.53000
LogP
4.16
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.510
InChIKey
XMLFPUBZFSJWCN-UHFFFAOYSA-N
SMILES
O=C(O)c1ccc(C(F)(F)F)cc1O
Safety Information
Hazard Codes
Xi: Irritant;
Risk Phrases
R36/37/38
Safety Phrases
26-36/37/39
HS Code
2918290000
Customs
HS Code
2918290000
Summary
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles23
More Articles
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
Eur. J. Pharm. Sci. 31(3-4) , 211-20, (2007)
In this research, the effects of micellar systems on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the mi...
A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.
Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011)
An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compa...
Salicylates increase insulin secretion in healthy obese subjects.
J. Clin. Endocrinol. Metab. 93(7) , 2523-30, (2008)
Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported.The objective of the study was to investigate the...
