Introduction：Basic information about CAS 101-31-5|Hyoscyamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.Target: mAChRHyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care [1].
Related Catalog
Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRNatural Products >>AlkaloidResearch Areas >>Neurological Disease
References
[1]. http://www.drugbank.ca/drugs/DB00424
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
429.8±45.0 °C at 760 mmHg
Melting Point
108.5ºC
Molecular Formula
C17H23NO3
Molecular Weight
289.369
Flash Point
213.7±28.7 °C
Exact Mass
289.167786
PSA
49.77000
LogP
1.53
Vapour Pressure
0.0±1.1 mmHg at 25°C
Index of Refraction
1.581
InChIKey
RKUNBYITZUJHSG-VFSICIBPSA-N
SMILES
CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
NH0875000
CHEMICAL NAME :
Hyoscyamine, (-)-
CAS REGISTRY NUMBER :
101-31-5
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H23-N-O3
MOLECULAR WEIGHT :
289.41
WISWESSER LINE NOTATION :
T56 A ANTJ A1 GOVYR&1Q -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1471 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,138,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1029 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
Safety Information
Hazard Codes
T+: Very toxic;
Risk Phrases
R26/28
Safety Phrases
24-45
RIDADR
UN 1544 6
WGK Germany
3
RTECS
NH0875000
HS Code
2933990090
Customs
HS Code
2933990090
Summary
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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