Introduction：Basic information about CAS 103884-98-6|2'-Deoxy-2'-fluoroguanosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-Deoxy-2'-fluoroguanosine |
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| CAS Number | 103884-98-6 | Molecular Weight | 285.23 |
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| Density | 2.2±0.1 g/cm3 | Boiling Point | 726.1ºC |
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| Molecular Formula | C10H12FN5O4 | Melting Point | / |
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| MSDS | / | Flash Point | 392.9ºC |
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Names
| Name | 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
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| Synonym | More Synonyms |
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2'-Deoxy-2'-fluoroguanosine BiologicalActivity
| Description | 2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Others |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 2.2±0.1 g/cm3 |
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| Boiling Point | 726.1ºC |
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| Molecular Formula | C10H12FN5O4 |
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| Molecular Weight | 285.23 |
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| Flash Point | 392.9ºC |
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| Exact Mass | 285.087341 |
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| PSA | 139.28000 |
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| LogP | -0.53 |
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| Vapour Pressure | 3.94E-22mmHg at 25°C |
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| Index of Refraction | 1.876 |
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| InChIKey | UXUZARPLRQRNNX-UHFFFAOYSA-N |
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| SMILES | Nc1nc2c(ncn2C2OC(CO)C(O)C2F)c(=O)[nH]1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UP0789000
- CHEMICAL NAME :
- 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro-
- CAS REGISTRY NUMBER :
- 103884-98-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C10-H12-F-N5-O4
- MOLECULAR WEIGHT :
- 285.27
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986
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Synonyms
| 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro- |
| 2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one |
| 2'-Deoxy-2'-fluoroguanosine |
| Guanosine, 2'-deoxy-2'-fluoro- |
