CAS 146255-66-5|(RS)-3,5-DHPG

Introduction:Basic information about CAS 146255-66-5|(RS)-3,5-DHPG, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(RS)-3,5-DHPG
CAS Number146255-66-5Molecular Weight183.16100
Density1.55g/cm3Boiling Point448.8ºC at 760mmHg
Molecular FormulaC8H9NO4Melting Point/
MSDS/Flash Point225.2ºC

Names

Name(S)-3,5-dihydroxyphenylglycine
SynonymMore Synonyms

(RS)-3,5-DHPG BiologicalActivity

DescriptionDHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].
Related CatalogSignaling Pathways >>GPCR/G Protein >>mGluR
Target

mGluR 1

mGluR 5

References

[1]. Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9.

[2]. Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43.

Chemical & Physical Properties

Density1.55g/cm3
Boiling Point448.8ºC at 760mmHg
Molecular FormulaC8H9NO4
Molecular Weight183.16100
Flash Point225.2ºC
Exact Mass183.05300
PSA103.78000
LogP0.88250
InChIKeyHOOWCUZPEFNHDT-UHFFFAOYSA-N
SMILESNC(C(=O)O)c1cc(O)cc(O)c1

Synonyms

(RS)-3,5-DHPG
tert-Butylisopentanal
HEXANAL,3,5,5-TRIMETHYL
Isononylaldehyde
3,5,5-Trimethylcapronaldehyde
3,5,5,-trimethylhexanal
Hexanal,3,5,5-trimethl
CAS 146233-39-8|Imidazo[1,2-b]pyridazine, methanone deriv
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