Introduction：Basic information about CAS 14737-89-4|3,4-Dimethoxycinnamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-Dimethoxycinnamic acid |
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| CAS Number | 14737-89-4 | Molecular Weight | 208.211 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 367.4±27.0 °C at 760 mmHg |
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| Molecular Formula | C11H12O4 | Melting Point | 181-183ºC(lit.) |
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| MSDS | / | Flash Point | 144.0±17.2 °C |
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Names
| Name | 3,4-dimethoxycinnamic acid |
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| Synonym | More Synonyms |
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3,4-Dimethoxycinnamic acid BiologicalActivity
| Description | (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Infection |
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| In Vitro | 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1]. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1]. |
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| References | [1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 367.4±27.0 °C at 760 mmHg |
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| Melting Point | 181-183ºC(lit.) |
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| Molecular Formula | C11H12O4 |
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| Molecular Weight | 208.211 |
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| Flash Point | 144.0±17.2 °C |
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| Exact Mass | 208.073563 |
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| PSA | 55.76000 |
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| LogP | 2.24 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.574 |
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| InChIKey | HJBWJAPEBGSQPR-GQCTYLIASA-N |
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| SMILES | COc1ccc(C=CC(=O)O)cc1OC |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 37/39-26 |
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| WGK Germany | 3 |
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Synonyms
| O-methylfagaronine chloride |
| 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)- |
| O-methylfagaronine |
| EINECS 219-025-5 |
| 3,4-DIMETHOXYCINNAMIC ACID |
| O-Methylferulic acid |
| MFCD00004387 |
| 3-(3,4-Dimethoxyphenyl)acrylic acid |
| 2-Methoxyfagaronine |
