CAS 24991-53-5|Polyethylene glycol diamine
| Common Name | Polyethylene glycol diamine | ||
|---|---|---|---|
| CAS Number | 24991-53-5 | Molecular Weight | 1000(Average) |
| Density | 1.003g/cm3 | Boiling Point | 241ºC at 760mmHg |
| Molecular Formula | (C2H4O)nC4H12N2O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | >110℃ |
| Symbol | GHS05, GHS08 | Signal Word | Danger |
Names
| Name | 2,2'-[1,2-Ethanediylbis(oxy)]diethanamine |
|---|---|
| Synonym | More Synonyms |
Polyethylene glycol diamine BiologicalActivity
| Description | PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR). |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| References | [1]. Han X, et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro. Int J Pharm. 2009 May 8;372(1-2):125-31. |
Chemical & Physical Properties
| Density | 1.003g/cm3 |
|---|---|
| Boiling Point | 241ºC at 760mmHg |
| Molecular Formula | (C2H4O)nC4H12N2O |
| Molecular Weight | 1000(Average) |
| Flash Point | >110℃ |
| Exact Mass | 148.12100 |
| PSA | 70.50000 |
| LogP | 0.33760 |
| Appearance of Characters | Granular Solid | White to off-white |
| Storage condition | −20°C |
| Water Solubility | Soluble in organic solvents. | It is soluble in organic solvents. It is insoluble in water. |
Safety Information
| Symbol | GHS05, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H318-H334 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R36/37/38;R42/43 |
| Safety Phrases | 22-24/25-45-36/37-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles22
More Articles| Synthesis of semitelechelic maleimide poly(PEGA) for protein conjugation by RAFT polymerization. Biomacromolecules 10(7) , 1777-81, (2009) Maleimide end functionalized polymers for site-selective conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. A fura... | |
| Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications. J. Org. Chem. 71(8) , 3051-63, (2006) A MUC1-related glycopeptide having five core-2 hexasaccharide branches (C330H527N46O207, MW = 8450.9) was synthesized by a new strategy using a combination of microwave-assisted solid-phase synthesis ... | |
| Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. J. Med. Chem. 45(10) , 1971-82, (2002) A one-bead-two-compound inhibitor library was synthesized by the split-mix method for the identification of inhibitors of a recombinant cysteine protease from Leishmania mexicana, CPB2.8DeltaCTE. The ... |
Synonyms
| α,ω-Diamino Poly(Ethylene Glycol) |
| MFCD00132004 |
| Poly(ethylene glycol) diamine |
| H2N-PEG-NH2 |
| Polyethylene glycol diamine |
| Poly(ethylene glycol) bis(amine) |
