Introduction：Basic information about CAS 10085-81-1|Benzoctamine Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzoctamine Hydrochloride |
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| CAS Number | 10085-81-1 | Molecular Weight | 285.81100 |
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| Density | / | Boiling Point | 372ºC at 760mmHg |
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| Molecular Formula | C18H20ClN | Melting Point | / |
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| MSDS | / | Flash Point | 181.1ºC |
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Names
| Name | Benzoctamine hydrochloride |
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| Synonym | More Synonyms |
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Benzoctamine Hydrochloride BiologicalActivity
| Description | Benzoctamine hydrochloride (Ba-30803) is a psychoactive agent with anti-anxiety effect. Benzoctamine hydrochloride blocks the central postsynaptic serotonin receptors and decreases 5-HT turnover in the brain[1][2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| In Vivo | Benzoctamine hydrochloride (Ba-30803) inhibits the head twitch reaction induced by L-5-hydroxytryptophan (5-HTP) in mice and by 5-methoxytryptamine (5-MT) in rats pretreated with tranylcypromine. Benzoctamine also antagonizes tryptamine (TRP)-induced clonic convulsions of forepaws in rats [2]. |
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| References | [1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575. [2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790. |
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Chemical & Physical Properties
| Boiling Point | 372ºC at 760mmHg |
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| Molecular Formula | C18H20ClN |
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| Molecular Weight | 285.81100 |
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| Flash Point | 181.1ºC |
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| Exact Mass | 285.12800 |
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| PSA | 12.03000 |
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| LogP | 4.62410 |
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| Vapour Pressure | 9.91E-06mmHg at 25°C |
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| InChIKey | NZPJYSIIKYJREH-UHFFFAOYSA-N |
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| SMILES | CNCC12CCC(c3ccccc31)c1ccccc12.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KJ4550000
- CHEMICAL NAME :
- 9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 10085-81-1
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C18-H19-N.Cl-H
- MOLECULAR WEIGHT :
- 285.84
- WISWESSER LINE NOTATION :
- L6 H666/GP 2AF P&&TTJ G1M1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,336,1972 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 51 mg/kg
- SEX/DURATION :
- female 2-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 49,1309,1973
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Synonyms
| Benzoctamine HCl |
| Tacitin |
| Tacitine |
| EINECS 233-216-0 |
| BA 30,803 |
