CAS 484049-04-9|DPH
| Common Name | DPH | ||
|---|---|---|---|
| CAS Number | 484049-04-9 | Molecular Weight | 336.32000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C18H13FN4O2 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione |
|---|---|
| Synonym | More Synonyms |
DPH BiologicalActivity
| Description | DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation. |
|---|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblResearch Areas >>Cancer |
| In Vitro | DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1]. |
| References | [1]. Yang J, et al. Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol. 2011 Feb 25;18(2):177-86 [2]. Shapiro LP, et al. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Mol Cell Neurosci. 2017 Oct 26;85:226-234. |
Chemical & Physical Properties
| Molecular Formula | C18H13FN4O2 |
|---|---|
| Molecular Weight | 336.32000 |
| Exact Mass | 336.10200 |
| PSA | 83.00000 |
| LogP | 2.47480 |
| InChIKey | MPQWYPLPWGUMJE-UHFFFAOYSA-N |
| SMILES | O=C1NC(=O)C(c2cn(-c3ccccc3)nc2-c2ccc(F)cc2)N1 |
| Storage condition | 2-8℃ |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
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Synonyms
| 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione |
| HMS2301N21 |
| 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione |
| DPH |
