Introduction：Basic information about CAS 943650-25-7|A-620223, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | A-620223 |
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| CAS Number | 943650-25-7 | Molecular Weight | 404.46000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H28N4O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | butanedioic acid,2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide |
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A-620223 BiologicalActivity
| Description | A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| References | [1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. |
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Chemical & Physical Properties
| Molecular Formula | C20H28N4O5 |
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| Molecular Weight | 404.46000 |
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| Exact Mass | 404.20600 |
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| PSA | 150.60000 |
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| LogP | 3.00910 |
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| InChIKey | GWFBXGWIRCSOAO-UHFFFAOYSA-N |
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| SMILES | CCCN1CCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1.O=C(O)CCC(=O)O |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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