Introduction：Basic information about CAS 246512-44-7|Gefitinib impurity 2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gefitinib impurity 2 |
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| CAS Number | 246512-44-7 | Molecular Weight | 309.36100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C15H23N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzamide |
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| Synonym | More Synonyms |
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Gefitinib impurity 2 BiologicalActivity
| Description | Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. |
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Chemical & Physical Properties
| Molecular Formula | C15H23N3O4 |
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| Molecular Weight | 309.36100 |
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| Exact Mass | 309.16900 |
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| PSA | 101.03000 |
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| LogP | 1.88070 |
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| InChIKey | HFUBNPPCNQAACT-UHFFFAOYSA-N |
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| SMILES | COc1cc(N)c(C(N)=O)cc1OCCCN1CCOCC1 |
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Synonyms
| 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide |
