Introduction：Basic information about CAS 1042672-97-8|IRAK inhibitor 6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IRAK inhibitor 6 |
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| CAS Number | 1042672-97-8 | Molecular Weight | 396.463 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H20N4O3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(2-methoxy-4-morpholin-4-ylphenyl)-2-pyridin-3-yl-1,3-thiazole-4-carboxamide |
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| Synonym | More Synonyms |
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IRAK inhibitor 6 BiologicalActivity
| Description | IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>IRAKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>IRAKResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 160 nM (IRAK-4)[1] |
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| In Vitro | IRAK inhibitor 6 significantly improves potency against IRAK-4. Potency effects additive, IRAK inhibitor 6 is the most active compound among these compound tested[1]. |
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| References | [1]. Buckley G, et al. IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C20H20N4O3S |
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| Molecular Weight | 396.463 |
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| Exact Mass | 396.125610 |
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| PSA | 108.31000 |
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| LogP | 1.59 |
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| Index of Refraction | 1.652 |
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| InChIKey | JQSRUVXPODZKAF-UHFFFAOYSA-N |
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| SMILES | COc1cc(N2CCOCC2)ccc1NC(=O)c1csc(-c2cccnc2)n1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 4-Thiazolecarboxamide, N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)- |
| CS-0602 |
| IRAK inhibitor 6 |
| N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-1,3-thiazole-4-carboxamide |
| X6124 |
| N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-4-carboxamide |
