CAS 1057249-41-8|SNS-314
Introduction：Basic information about CAS 1057249-41-8|SNS-314, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SNS-314 | ||
|---|---|---|---|
| CAS Number | 1057249-41-8 | Molecular Weight | 430.934 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C18H15ClN6OS2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea |
|---|---|
| Synonym | More Synonyms |
SNS-314 BiologicalActivity
| Description | SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>Aurora KinaseResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Aurora Kinase |
| Target | Aurora A:9 nM (IC50) Aurora B:31 nM (IC50) Aurora C:6 nM (IC50) |
| In Vitro | SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells[2]. |
| In Vivo | In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2]. |
| References | [1]. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. [2]. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H15ClN6OS2 |
| Molecular Weight | 430.934 |
| Exact Mass | 430.043732 |
| PSA | 155.03000 |
| LogP | 5.36 |
| Index of Refraction | 1.815 |
| InChIKey | FAYAUAZLLLJJGH-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 |
| Storage condition | -20℃ |
Synonyms
| 1-(3-Chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea |
| Kinome_3712 |
| Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]- |
| SN-314 |
| AK2 |
| UNII-802IFJ0Z8X |
| SNS 314 |
| N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea |
