CAS 101526-83-4|Sematilide

Introduction：Basic information about CAS 101526-83-4|Sematilide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sematilide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Sematilide
CAS Number	101526-83-4	Molecular Weight	313.41600
Density	1.205 g/cm3	Boiling Point	/
Molecular Formula	C₁₄H₂₃N₃O₃S	Melting Point	141-142 °C
MSDS	/	Flash Point	/

Names

Name	N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide
Synonym	More Synonyms

Sematilide BiologicalActivity

Description	Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
Target	IC50: 25 μM (K+ current)[1]
In Vitro	Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].
In Vivo	Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2]. Animal Model: Mongrel dogs of either sex (10-18 kg body weight)[2] Dosage: 0.3, 1, 3, and 10 mg/kg Administration: I.v. infusions Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
References	[1]. Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331(2-3):295-302. [2]. Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.

Chemical & Physical Properties

Density	1.205 g/cm3
Melting Point	141-142 °C
Molecular Formula	C₁₄H₂₃N₃O₃S
Molecular Weight	313.41600
Exact Mass	313.14600
PSA	86.89000
LogP	2.67440
Index of Refraction	1.558
InChIKey	KHYPYQZQJSBPIX-UHFFFAOYSA-N
SMILES	CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1

Safety Information

HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

C14H23N3O3S

UNII-0NHB13IN3R

Sematilide

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