Introduction：Basic information about CAS 882663-88-9|AMG-47a, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AMG-47a |
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| CAS Number | 882663-88-9 | Molecular Weight | 535.560 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C29H28F3N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide |
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| Synonym | More Synonyms |
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AMG-47a BiologicalActivity
| Description | AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.IC50 value: Target: Lck inhibitorIn several other in vitro assays, AMG-47a displays subnanomolar inhibition against Lck, and low (<10 nM) inhibition against other hard to inhibit kinases such as KDR and SRC and MAPK α (p38α). In addition, at slightly higher doses but well under 10 μM, AMG-47a effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2 μM. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcResearch Areas >>Inflammation/Immunology |
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| References | [1]. Carver J, et al. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein. PLoS One. 2014 Aug 5;9(8):e103836. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C29H28F3N5O2 |
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| Molecular Weight | 535.560 |
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| Exact Mass | 535.219482 |
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| PSA | 86.10000 |
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| LogP | 5.38 |
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| Index of Refraction | 1.637 |
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| InChIKey | DVRSTRMZTAPMKO-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 4-Methyl-3-(2-{[2-(4-morpholinyl)ethyl]amino}-6-quinazolinyl)-N-[3-(trifluoromethyl)phenyl]benzamide |
| 4-methyl-3-(2-{[2-(morpholin-4-yl)ethyl]amino}quinazolin-6-yl)-N-[3-(trifluoromethyl)phenyl]benzamide |
| AMG-47a |
| AMG-47 |
| Benzamide, 4-methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]- |
