Introduction：Basic information about CAS 621-72-7|bendazol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | bendazol |
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| CAS Number | 621-72-7 | Molecular Weight | 208.258 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 453.5±24.0 °C at 760 mmHg |
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| Molecular Formula | C14H12N2 | Melting Point | 187ºC |
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| MSDS | / | Flash Point | 252.1±9.3 °C |
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Names
| Name | 2-Benzyl-1H-benzimidazole |
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| Synonym | More Synonyms |
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bendazol BiologicalActivity
| Description | Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Cardiovascular Disease |
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| Target | NO synthase[1] |
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| References | [1]. Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 453.5±24.0 °C at 760 mmHg |
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| Melting Point | 187ºC |
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| Molecular Formula | C14H12N2 |
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| Molecular Weight | 208.258 |
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| Flash Point | 252.1±9.3 °C |
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| Exact Mass | 208.100052 |
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| PSA | 28.68000 |
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| LogP | 3.93 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.680 |
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| InChIKey | YTLQFZVCLXFFRK-UHFFFAOYSA-N |
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| SMILES | c1ccc(Cc2nc3ccccc3[nH]2)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DD6206000
- CHEMICAL NAME :
- Benzimidazole, 2-benzyl-
- CAS REGISTRY NUMBER :
- 621-72-7
- BEILSTEIN REFERENCE NO. :
- 0159495
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C14-H12-N2
- MOLECULAR WEIGHT :
- 208.28
- WISWESSER LINE NOTATION :
- T56 BM DNJ C1R
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (1),44,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(6),25,1990
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 504 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,829,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2292473
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (5),26,1983 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2942000000 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 210-703-6 |
| bendazol |
| 2-benzylbenzIMIDAZOLE |
| MFCD00022680 |
| 2-Benzyl-1H-benzimidazole |
| 1H-Benzimidazole, 2-(phenylmethyl)- |
| bendazole |
