CAS 6665-83-4|6-Monohydroxyflavone

Introduction：Basic information about CAS 6665-83-4|6-Monohydroxyflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 6-Monohydroxyflavone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	6-Monohydroxyflavone
CAS Number	6665-83-4	Molecular Weight	238.238
Density	1.3±0.1 g/cm3	Boiling Point	450.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀O₃	Melting Point	234-236 °C(lit.)
MSDS	/	Flash Point	176.3±22.2 °C

Names

Name	6-Hydroxyflavone
Synonym	More Synonyms

6-Monohydroxyflavone BiologicalActivity

Description	6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52. [2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560. [3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

Description

6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology

References

[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

[2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	450.1±45.0 °C at 760 mmHg
Melting Point	234-236 °C(lit.)
Molecular Formula	C₁₅H₁₀O₃
Molecular Weight	238.238
Flash Point	176.3±22.2 °C
Exact Mass	238.062988
PSA	50.44000
LogP	3.72
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.666
InChIKey	GPZYYYGYCRFPBU-UHFFFAOYSA-N
SMILES	O=c1cc(-c2ccccc2)oc2ccc(O)cc12

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
WGK Germany	3
HS Code	2914400090

Customs

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Synonyms

EINECS 229-704-8

4H-1-Benzopyran-4-one, 6-hydroxy-2-phenyl-

6-Monohydroxyflavone

MFCD00017329

6-hydroxy-2-phenylchromen-4-one

6-Hydroxy-2-phenyl-4H-chromen-4-one

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