Introduction：Basic information about CAS 6980-25-2|Swertiajaponin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Swertiajaponin |
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| CAS Number | 6980-25-2 | Molecular Weight | 462.404 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 761.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H22O11 | Melting Point | / |
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| MSDS | / | Flash Point | 266.6±26.4 °C |
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Names
| Name | swertiajaponin |
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| Synonym | More Synonyms |
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Swertiajaponin BiologicalActivity
| Description | Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase |
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| Target | IC50: 43.47 μM (tyrosinase)[1] |
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| References | [1]. Lee B, et al. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase. Oncotarget. 2017 Sep 15;8(56):95530-95541. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 761.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H22O11 |
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| Molecular Weight | 462.404 |
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| Flash Point | 266.6±26.4 °C |
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| Exact Mass | 462.116211 |
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| PSA | 190.28000 |
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| LogP | 1.83 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.717 |
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| InChIKey | DLVLXOYLQKCAME-DGHBBABESA-N |
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| SMILES | COc1cc2oc(-c3ccc(O)c(O)c3)cc(=O)c2c(O)c1C1OC(CO)C(O)C(O)C1O |
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| Storage condition | 2-8℃ |
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Synonyms
| Swertiajaponin |
| D-Glucitol, 1,5-anhydro-1-C-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)- |
| (1S)-1,5-Anhydro-1-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol |
| Leucanthoside |
| 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one |
