CAS 17391-18-3|Corynoxine B

Introduction：Basic information about CAS 17391-18-3|Corynoxine B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Corynoxine B BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Corynoxine B
CAS Number	17391-18-3	Molecular Weight	384.469
Density	1.2±0.1 g/cm3	Boiling Point	560.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈N₂O₄	Melting Point	/
MSDS	/	Flash Point	293.0±30.1 °C

Names

Name	rhynchophylline
Synonym	More Synonyms

Corynoxine B BiologicalActivity

Description	Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].
Related Catalog	Signaling Pathways >>Autophagy >>AutophagyNatural Products >>AlkaloidResearch Areas >>Cancer
References	[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. [2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

Description

Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].

Related Catalog

Signaling Pathways >>Autophagy >>AutophagyNatural Products >>AlkaloidResearch Areas >>Cancer

References

[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54.

[2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	560.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.469
Flash Point	293.0±30.1 °C
Exact Mass	384.204895
PSA	67.87000
LogP	3.31
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.596
InChIKey	DAXYUDFNWXHGBE-XYEDMTIPSA-N
SMILES	CCC1CN2CCC3(C(=O)Nc4ccccc43)C2CC1C(=COC)C(=O)OC
Storage condition	-20°C

Synonyms

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,3R,6'S,7'S,8'aS)-

Corynoxine B

Methyl (7β,16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate

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