CAS 607-80-7|Sesamin
| Common Name | Sesamin | ||
|---|---|---|---|
| CAS Number | 607-80-7 | Molecular Weight | 354.353 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 504.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H18O6 | Melting Point | 122-124ºC |
| MSDS | ChineseUSA | Flash Point | 212.3±30.0 °C |
Names
| Name | (+)-sesamin |
|---|---|
| Synonym | More Synonyms |
Sesamin BiologicalActivity
| Description | Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | delta 5 desaturase[1] |
| In Vitro | Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated[1]. |
| In Vivo | Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)[1]. |
| References | [1]. Cheng FC, et al. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2006 Sep;2(3):284-8. [2]. Shimizu S, et al. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acidbiosynthesis. Lipids. 1991 Jul;26(7):512-6. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 504.4±50.0 °C at 760 mmHg |
| Melting Point | 122-124ºC |
| Molecular Formula | C20H18O6 |
| Molecular Weight | 354.353 |
| Flash Point | 212.3±30.0 °C |
| Exact Mass | 354.110352 |
| PSA | 55.38000 |
| LogP | 3.32 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.623 |
| InChIKey | PEYUIKBAABKQKQ-AFHBHXEDSA-N |
| SMILES | c1cc2c(cc1C1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2 |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles47
More Articles| Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition. Sci. Rep. 4 , 5896, (2014) Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the... | |
| Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.). Mol. Biol. Rep. 39(6) , 6867-73, (2012) Metabolic transformations of two substrates for human cytochrome P450 (CYP450) 2C9, tolbutamide and diclofenac, were investigated in hepatic microsomes from Atlantic salmon (Salmo salar L.). Tolbutami... | |
| Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense. Eur. J. Nutr. 53(8) , 1659-68, (2014) Nutritional control has been proposed as a potential therapy for slowing the senescence of immune function and decreasing mortality. This study investigated whether sesamin could modify host defense s... |
Synonyms
| Sesamin |
| (7S,7’S,8R,8’R)-sesamin |
| 5,5'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) |
| (+)-Sesamin |
| Pseudocubebin |
| d-Sesamin |
| SesameP.E. |
| SezaMin |
| 1,3-Benzodioxole, 5,5'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis- |
| FAGAROL |
