CAS 537-73-5|Isoferulic acid

Introduction：Basic information about CAS 537-73-5|Isoferulic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isoferulic acid BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles47
8. Synonyms

Common Name	Isoferulic acid
CAS Number	537-73-5	Molecular Weight	194.184
Density	1.3±0.1 g/cm3	Boiling Point	410.2±35.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₀O₄	Melting Point	230 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	167.6±19.4 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	3-Hydroxy-4-methoxycinnamic acid
Synonym	More Synonyms

Isoferulic acid BiologicalActivity

Description	3-Hydroxy-4-methoxycinnamic acid (Isoferulic acid) is a cinnamic acid derivative that has antidiabetic activity. 3-Hydroxy-4-methoxycinnamic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Metabolic DiseaseNatural Products >>Phenylpropanoids
References	[1]. Liu IM, et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	410.2±35.0 °C at 760 mmHg
Melting Point	230 °C (dec.)(lit.)
Molecular Formula	C₁₀H₁₀O₄
Molecular Weight	194.184
Flash Point	167.6±19.4 °C
Exact Mass	194.057907
PSA	66.76000
LogP	1.56
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.627
Storage condition	-20?C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD3365400

CHEMICAL NAME :: 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 537-73-5

BEILSTEIN REFERENCE NO. :: 2212760

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H10-O4

MOLECULAR WEIGHT :: 194.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 95,539,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 95,539,1975

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UD3365400
HS Code	29189090

Customs

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles47

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC-ESI-MS/MS.

Talanta 128 , 221-30, (2014)

An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study ...

Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling

J. Chromatogr. A. 1218(23) , 3689-94, (2011)

We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of io...

Synonyms

3'-hydroxy-4'-methoxy cinnamic acid

Hesperitinic acid

trans-Isoferulic acid

2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-, (2E)-

RARECHEM BK HW 0093

trans-3-hydroxy-4-methoxycinnamic acid

3-Hydroxy-4-MethoxycinnaMic Acid

3-(3-Hydroxy-4-methoxyphenyl)acrylic acid

3-Hydroxy-4-methoxycinnamic

Isoferulic acid

HESPERETINIC ACID

Isoferulate

MFCD00004391

EINECS 208-676-0

Isoferulic

Caffeic acid 4-methyl ether

(2E)-3-(3-Hydroxy-4-methoxyphenyl)acrylic acid

3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid

Hesperetic acid

(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid

3-hydroxy-4-methoxy-Cinnamic acid

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