Introduction：Basic information about CAS 6926-08-5|Harpagide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Harpagide |
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| CAS Number | 6926-08-5 | Molecular Weight | 364.345 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | 637.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C15H24O10 | Melting Point | / |
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| MSDS | / | Flash Point | 339.1±31.5 °C |
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Names
| Name | Harpagide |
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| Synonym | More Synonyms |
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Harpagide BiologicalActivity
| Description | Harpagide is a class of iridoid glycoside isolated from Scrophularia cryptophila and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2]. |
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| Related Catalog | Research Areas >>Infection |
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| In Vitro | Harpagide shows cytotoxic activity over 50% in a concentration of 90 μg/mL, Harpagide on the A431 and HeLa cell lines. The cytotoxic effect of Harpagide on the MCF7 cell line in a concentration of 90 μg/mL[3]. |
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| References | [1]. Tasdemir D, et al. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine. 2008 Mar;15(3):209-15. [2]. Zhang L, et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882-6. [3]. Háznagy-Radnai E, et al. Cytotoxic activities of Stachys species. Fitoterapia. 2008 Dec;79(7-8):595-7. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 637.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C15H24O10 |
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| Molecular Weight | 364.345 |
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| Flash Point | 339.1±31.5 °C |
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| Exact Mass | 364.136932 |
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| PSA | 169.30000 |
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| LogP | -3.69 |
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| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
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| Index of Refraction | 1.663 |
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| InChIKey | XUWSHXDEJOOIND-UHFFFAOYSA-N |
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| SMILES | CC1(O)CC(O)C2(O)C=COC(OC3OC(CO)C(O)C(O)C3O)C12 |
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Safety Information
Synonyms
| 4a,5,7-Trihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-yl hexopyranoside |
| einecs 230-050-0 |
| Hexopyranoside, 1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta[c]pyran-1-yl |
