Introduction：Basic information about CAS 487-41-2|Phillyrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Phillyrin |
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| CAS Number | 487-41-2 | Molecular Weight | 534.552 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 730.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H34O11 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 395.5±32.9 °C |
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Names
| Name | forsythin |
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| Synonym | More Synonyms |
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Phillyrin BiologicalActivity
| Description | Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | CYP1A2; CYP2D1[1] |
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| In Vitro | Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1]. Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1]. RT-PCR[1] Cell Line: Human HepG2 hepatocyte cells Concentration: 1 μM; 2.5 μM; 5 μM Incubation Time: 24 hours Result: Reduced FAS and SREBP-1c mRNA expression. |
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| References | [1]. Cheng Y, et al. Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro. Xenobiotica. 2017 Apr;47(4):297-303. [2]. Do MT, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013 Jan 15;136(2):415-25. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 730.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H34O11 |
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| Molecular Weight | 534.552 |
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| Flash Point | 395.5±32.9 °C |
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| Exact Mass | 534.210083 |
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| PSA | 145.53000 |
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| LogP | 0.08 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.596 |
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Safety Information
| Hazard Codes | C |
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| Safety Phrases | 22-24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 29389090 |
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Synonyms
| β-D-Glucopyranoside, 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl |
| Pillyrin |
| Chionanthin |
| 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-glucopyranoside |
| PHILLYRIN |
| Phillyroside |
| phyllyrin |
| [1S-(1a,3aa,4b,6aa)]-4-[4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl-b-D-glucopyranoside |
