CAS 17605-67-3|Fucosterol
| Common Name | Fucosterol | ||
|---|---|---|---|
| CAS Number | 17605-67-3 | Molecular Weight | 412.69100 |
| Density | 0.98 g/cm3 | Boiling Point | 504.2ºC at 760 mmHg |
| Molecular Formula | C29H48O | Melting Point | 118-120ºC |
| MSDS | ChineseUSA | Flash Point | 220.3ºC |
Names
| Name | fucosterol |
|---|---|
| Synonym | More Synonyms |
Fucosterol BiologicalActivity
| Description | Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
| Target | PPARα; C/EBPα[1] |
| In Vitro | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1].Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3]. Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. Cell Viability Assay[1] Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression. |
| In Vivo | Fucosterol (orally adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2]. |
| References | [1]. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20. [2]. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2. [3]. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4. [4]. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8. |
Chemical & Physical Properties
| Density | 0.98 g/cm3 |
|---|---|
| Boiling Point | 504.2ºC at 760 mmHg |
| Melting Point | 118-120ºC |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.69100 |
| Flash Point | 220.3ºC |
| Exact Mass | 412.37100 |
| PSA | 20.23000 |
| LogP | 7.94490 |
| Vapour Pressure | 2.8E-12mmHg at 25°C |
| Index of Refraction | 1.53 |
| InChIKey | OSELKOCHBMDKEJ-HRKULPSGSA-N |
| SMILES | CC=C(CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles27
More Articles| Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera. Chem. Biol. Interact. 206(1) , 55-62, (2013) In the present study, we investigated the anti-diabetic potential of fucosterol by evaluating the ability of this compound to inhibit rat lens aldose reductase (RLAR), human recombinant aldose reducta... | |
| The effect of traditional stir-frying process on hydrophilic and lipophilic antioxidant capacities of pine nut kernels. Int. J. Food Sci. Nutr. 66 , 873-80, (2015) The effect of traditional stir-frying process at different heating temperatures (50-150 °C) and time periods (5-20 min) on hydrophilic part (total and individual phenolics), lipophilic part (tocophero... | |
| Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens. J. Nat. Prod. 64(11) , 1463-4, (2001) Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was ... |
Synonyms
| trans-24-Ethylidenecholesterol |
| D5-avenasterol |
| MFCD00037543 |
| FUCOSTEROL |
| Fucosterin |
| trans-Stigmasta-5,24(28)-dien-3b-ol |
| 24-ETHYLIDENCHOLEST-5-ENE-3B-OL |
