CAS 93413-69-5|Venlafaxine

Introduction：Basic information about CAS 93413-69-5|Venlafaxine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Venlafaxine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Venlafaxine
CAS Number	93413-69-5	Molecular Weight	277.402
Density	1.1±0.1 g/cm3	Boiling Point	397.6±27.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₇NO₂	Melting Point	72-74°C
MSDS	/	Flash Point	194.2±23.7 °C

Names

Name	venlafaxine
Synonym	More Synonyms

Venlafaxine BiologicalActivity

Description	Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.Target: SNRIVenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.Venlafaxine is a bicyclic antidepressant, and usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It works by blocking the transporter "reuptake" proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine, with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters; therefore, venlafaxine can increase dopamine neurotransmission in this part of the brain. Venlafaxine interacts with opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as narcotics become increasingly used as a measure of last resort for refractory cases.
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Serotonin TransporterResearch Areas >>Neurological DiseaseNatural Products >>Others
References	[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80. [2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.

Description

Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.Target: SNRIVenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.Venlafaxine is a bicyclic antidepressant, and usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It works by blocking the transporter "reuptake" proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine, with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters; therefore, venlafaxine can increase dopamine neurotransmission in this part of the brain. Venlafaxine interacts with opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as narcotics become increasingly used as a measure of last resort for refractory cases.

Related Catalog

Signaling Pathways >>Neuronal Signaling >>Serotonin TransporterResearch Areas >>Neurological DiseaseNatural Products >>Others

References

[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

[2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	397.6±27.0 °C at 760 mmHg
Melting Point	72-74°C
Molecular Formula	C₁₇H₂₇NO₂
Molecular Weight	277.402
Flash Point	194.2±23.7 °C
Exact Mass	277.204193
PSA	32.70000
LogP	2.91
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.544
InChIKey	PNVNVHUZROJLTJ-UHFFFAOYSA-N
SMILES	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1
Storage condition	Refrigerator, Under Inert Atmosphere

Safety Information

Hazard Codes	Xn
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin . R20/22:Harmful by inhalation and if swallowed .
Safety Phrases	S37/39-S26
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Efectin

N,N-Dimethyl-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethylamine

Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-

1-(2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol

(±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol

DL-Venlafaxine

MFCD03658865

Trevilor

Venlafaxine

(±)-1-[α-[(Dimethylamino)methyl]-p-methoxybenzyl]cyclohexanol

1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol

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