CAS 122-99-6|Phenoxyethanol

[1]. B Dréno, et al. Safety Review of Phenoxyethanol When Used as a Preservative in Cosmetics. J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:15-24.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KM0350000

CHEMICAL NAME :

Ethanol, 2-phenoxy-

CAS REGISTRY NUMBER :

122-99-6

BEILSTEIN REFERENCE NO. :

1364011

LAST UPDATED :

199710

DATA ITEMS CITED :

22

MOLECULAR FORMULA :

C8-H10-O2

MOLECULAR WEIGHT :

138.18

WISWESSER LINE NOTATION :

Q2OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1260 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

14422 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

554 mg/kg

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

933 mg/kg

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

490 mg/kg

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

5 mL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

182 gm/kg/13W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

17500 mg/kg/14D-I

TOXIC EFFECTS :

Gastrointestinal - alteration in gastric secretion Blood - other changes Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15 mg/m3/9W-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Liver - liver function tests impaired

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3 gm/kg/10D-I

TOXIC EFFECTS :

Behavioral - general anesthetic Kidney, Ureter, Bladder - other changes in urine composition Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

14 gm/kg/14D-I

TOXIC EFFECTS :

Blood - other changes Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

Mutation test systems - not otherwise specified

TEST SYSTEM :

Bacteria - Escherichia coli

DOSE/DURATION :

2000 ppm

REFERENCE :

MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 28,7,1980 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83449 No. of Facilities: 711 (estimated) No. of Industries: 18 No. of Occupations: 19 No. of Employees: 9560 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83449 No. of Facilities: 5523 (estimated) No. of Industries: 63 No. of Occupations: 77 No. of Employees: 111040 (estimated) No. of Female Employees: 46637 (estimated)

Oncogene 33(21) , 2717-27, (2014)

RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell growth and tissue development through their distinct signaling pathways. Although much has been learnt about their...

J. Exp. Biol. 218 , 2610-9, (2015)

Using rainbow trout fed with low-fat or high-fat diets, we aimed to determine whether the response of food intake, mRNA abundance of hypothalamic neuropeptides involved in the metabolic regulation of ...

Dev. Comp. Immunol. 54 , 55-65, (2015)

The C-type lectin domain containing (CLEC) receptors including CD209 are expressed in vivo by monocytes, monocyte-derived macrophages and dendritic cells and by in vitro generated monocyte-derived cel...