CAS 18472-51-0|Chlorhexidine digluconate

Introduction：Basic information about CAS 18472-51-0|Chlorhexidine digluconate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chlorhexidine digluconate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles23
8. Synonyms

Common Name	Chlorhexidine digluconate
CAS Number	18472-51-0	Molecular Weight	897.757
Density	1.06 g/mL at 25 °C(lit.)	Boiling Point	699.3ºC at 760 mmHg
Molecular Formula	C₃₄H₅₄Cl₂N₁₀O₁₄	Melting Point	134ºC
MSDS	Chinese	Flash Point	376.7ºC
Symbol	GHS09	Signal Word	Warning

Names

Name	chlorhexidine gluconate
Synonym	More Synonyms

Chlorhexidine digluconate BiologicalActivity

Description	Chlorhexidine is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.Target: AntibacterialChlorhexidine is a chemical antiseptic.It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions [1, 2].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Jenkins, S., M. Addy, and W. Wade, The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol, 1988. 15(7): p. 415-24. [2]. Maki, D.G., M. Ringer, and C.J. Alvarado, Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet, 1991. 338(8763): p. 339-43.

Description

Chlorhexidine is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.Target: AntibacterialChlorhexidine is a chemical antiseptic.It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions [1, 2].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Jenkins, S., M. Addy, and W. Wade, The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol, 1988. 15(7): p. 415-24.

[2]. Maki, D.G., M. Ringer, and C.J. Alvarado, Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet, 1991. 338(8763): p. 339-43.

Chemical & Physical Properties

Density	1.06 g/mL at 25 °C(lit.)
Boiling Point	699.3ºC at 760 mmHg
Melting Point	134ºC
Molecular Formula	C₃₄H₅₄Cl₂N₁₀O₁₄
Molecular Weight	897.757
Flash Point	376.7ºC
Exact Mass	896.319824
PSA	444.48000
Vapour Pressure	0mmHg at 25°C
InChIKey	YZIYKJHYYHPJIB-UUPCJSQJSA-N
SMILES	NC(=NCCCCCCN=C(N)N=C(N)Nc1ccc(Cl)cc1)N=C(N)Nc1ccc(Cl)cc1.O=C(O)C(O)C(O)C(O)C(O)CO.O=C(O)C(O)C(O)C(O)C(O)CO

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1950000

CAS REGISTRY NUMBER :: 18472-51-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C22-H30-Cl2-N10.2C6-H12-O7

MOLECULAR WEIGHT :: 897.88

WISWESSER LINE NOTATION :: GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QVYQYQYQYQ1Q 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 1 mg/L

REFERENCE :: ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- Volume(issue)/page/year: 32,171,1986 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3093 No. of Facilities: 4592 (estimated) No. of Industries: 5 No. of Occupations: 36 No. of Employees: 643404 (estimated) No. of Female Employees: 561783 (estimated)

Safety Information

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes	N
Risk Phrases	50/53
Safety Phrases	61
RIDADR	UN 3082 9 / PGIII
WGK Germany	-
HS Code	3004909090

Customs

HS Code	3004909090

Articles23

Superficial roughness on composite surface, composite enamel and composite dentin junctions after different finishing and polishing procedures. Part I: roughness after treatments with tungsten carbide vs diamond burs.

Int. J. Esthet. Dent. 9(1) , 70-89, (2014)

The aim of this study is to investigate different instruments for finishing composite restorations, as well as examining different surfaces and interfaces of the same restoration. The null hypothesis ...

TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis.

J. Am. Soc. Nephrol. 24(10) , 1627-42, (2013)

Peritoneal fibrosis (PF) causes ultrafiltration failure (UFF) and is a complicating factor in long-term peritoneal dialysis. Lymphatic reabsorption also may contribute to UFF, but little is known abou...

Incorporation of chlorhexidine gluconate or diacetate into a glass-ionomer cement: porosity, surface roughness, and anti-biofilm activity.

Am. J. Dent. 27(6) , 318-22, (2014)

To evaluate the porosity, surface roughness and anti-biofilm activity of a glass-ionomer cement (GIC) after incorporation of different concentrations of chlorhexidine (CHX) gluconate or diacetate.For ...

Synonyms

Maskin

Unisept

Chlorhexamed

1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane

Septeal

(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid - N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] (2:1)

Betasept

N,N''''-1,6-Hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)

N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di-D-gluconate

Peridex

Rotersept

hibitane

Manusan

chlorohexidine digluconate

Chlorhexidin Bigluconate

N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)

MFCD00083599

Chlorhexidine gluconate

disteryl

chlorhexidine gigluconate

D-Gluconic Acid compd. with N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

Hibident

Plurexid

Hibidil

N,N''''-Hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)

1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

chlorhexidine bigluconate

EINECS 242-354-0

STERILON

4-CHLORHEXIDINE DIGLUCONATE

Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, compd. with D-gluconic acid (1:2)

Corsodyl

UNII-MOR84MUD8E

chlorhexidine D-digluconate

chlorhexidine di-D-gluconate

Hibiscrub

Maskin R

Hibisol

1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate

Hexidine

1,1‘-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

pHiso-Med

orahexal

placout

Chlorhexidine digluconate

abacil

Chlorhexidine (digluconate)

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